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--南方医科大学皮肤病医院(广东省皮肤病医院) 发布时间:2023/6/26    【访问量:4130】 --
 

教授,博士研究生导师。海外高层次人才青年计划专家,皮肤病研究所所长。
清华大学生物学学士、博士,美国加州大学圣迭戈分校(UCSD)博士后。研究方向为结合基因编辑技术、小鼠模型、人源类器官和病人样本,研究肺和皮肤的再生医学。主要解析纤维化皮肤病及其他皮肤病的发病机制,寻找治疗的潜在全新分子和细胞靶点,开发基因编辑新工具,最终利用新靶点和新工具探索皮肤病的新疗法。以通讯作者或第一作者在Cell Stem Cell, Nucleic Acids Res, Genome Biol, Nat Commun, Cell Res, Protein & Cell, Cell Rep, J Invest Dermatol等SCI学术期刊发表论文50余篇,累及引用3500余次(Google Scholar);参与撰写基因编辑专著1部,申请国际PCT专利3项,中国发明专利10项(授权6项);曾任国际SCI期刊 Journal of Gene Medicine副主编,主持和参与国家科技重大专项、国家自然科学基金重点和面上项目、广东省和广州市重点项目等多项课题。
代表性论文
1. Huang, T. #, Chen S. #, Ding, K., Zheng, B., Lv, W., Wang, X., Zhong, Y., Huang, H., Zhang, X., Ma, S., Yang, B.*, Wang, X.*, Rong, Z.* SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis. Cell Death Dis 14, 354 (2023)
2. Ma, S., Liao, K., Li, M., Wang, X., Lv, J., Zhang, X., Huang, H., Li, L., Huang, T., Guo, X.*, Lin, Y.*, Rong, Z.* Phase-separated DropCRISPRa platform for efficient gene activation in mammalian cells and mice. Nucleic Acids Res 51, 5271-5284 (2023)
3. Gu, J.J. #, Deng, C.C. #, Feng, Q.L., Liu, J., Zhu, D.H., Cheng, Q, Rong, Z.*, Yang, B.* Relief of extracellular matrix deposition repression by downregulation of IRF1-mediated TWEAK/Fn14 signaling in keloids. J Invest Dermatol Published online (2023)
4. Deng, C.C. #, Zhang, L.X. #, Xu, X.Y. #, Zhu, D.H., Cheng, Q., Ma, S., Rong, Z.*, Yang, B.* Risk SNP-mediated enhancer-promoter interaction drives keloid through lncRNA DEIK. Br J Dermatol 188, 84-93 (2023) 
Commented by Br J Dermatol (188: 7)
5. Deng, C.C. #, Hu, Y.F. #, Zhu, D.H. #, Cheng, Q., Gu, J.J., Feng, Q.L., Zhang, L.X., Xu, Y.P., Wang, D., Rong, Z.*, Yang, B.* Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases. Nat Commun 12, 3709 (2021)
6. Liu, J.#, Chen, J.#, Zhong, Y., Yu, X., Lu, P., Feng, J., Zhang, X., Ma, S., Yang, C., Yang, B.*, Rong, Z.* OSMRβ mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients. Protein & Cell 12, 653-661 (2021)
7. Xue, Y.#, Chen, W.#, Mai, Z., Yu, X., Wu, Q., Wan, C., Su, X., Wu, Y., Rong, Z.*, Zheng, H*. Inhibition of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Cascade Limits Chlamydia trachomatis infection. J Invest Dermatol 141, 852-862 (2021)
8. Ma, S., Wang, X., Hu, Y., Lv, J., Liu, C., Liao, K., Guo, X., Wang, D., Lin, Y.*, Rong, Z.* Enhancing site-specific DNA integration by a Cas9 nuclease fused with a DNA donor-binding domain. Nucleic Acids Res 48, 10590-10601 (2020)
9. Deng, C.C.#, Zhu, D.H.#, Chen, Y.J., Huang, T.Y., Peng, Y., Liu, S.Y., Lu, P., Xue, Y.H., Xu, Y.P., Yang, B.*, Rong, Z.* TRAF4 promotes fibroblast proliferation in keloids by destabilizing p53 via interacting with the deubiquitinase USP10. J Invest Dermatol 139, 1925-1935 (2019)
10. Rong, Z., Wang, M., Hu, Z., Stradner, M., Zhu, S., Kong, H., Yi, H., Goldrath, A., Yang, Y.G., Xu, Y., Fu, X. An effective approach to prevent immune rejection of human ESC-derived allografts. Cell Stem Cell 14, 121-130 (2014)

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