个人简介
中山大学孙逸仙纪念医院皮肤科教授，主任医师，博士生导师。南方医科大学皮肤病医院特聘教授，博士生导师。中国菌物学会前任副理事长及医真菌专委会前任主任委员。现任亚太真菌学会理事、中国女医师协会皮肤科分会常委，中华医学会细菌感染与耐药防治分会委员、中国中西医结合分会皮肤病学分会委员。多年致力于马尔尼菲蓝状菌及着色霉致病性研究。曾在日本千叶大学真菌医学研究中心、美国佛吉尼亚大学、哈佛医学院麻州总院光医学中心、美国乔治城大学及荷兰皇家科学院真菌生物多样性中心等访问研究。先后主持国家自然科学基金9项（包括一项联合重点项目），主持卫生部公益项目、国家重大传染病专项分项目课题各1项。“马尔尼菲青霉毒力因子相关研究”获2014年华夏医疗保健国际交流促进科技奖三等奖。发表SCI文章100余篇。
研究领域
主要研究方向地域性真菌病马尔尼菲蓝状菌病和中国南方暗色真菌（着色真菌）致病性研究。近十年承担的科研项目有：
1. 异柠檬酸裂解酶对马尔尼菲篮状菌细胞壁的调控影响巨噬细胞自噬作用的机制研究。国家自然科学基金（面上项目），资助金额：56万，2022-01-01 – 2025-12-31。项目批准号：82172289；项目负责人：席丽艳
2. Monophora着色霉黑素抵抗宿主中性粒细胞杀伤的作用机制研究。国家自然科学基金（面上项目），资助金额：57万，2019-01-01至2022-12-31。项目批准号：81873960；项目负责人：席丽艳
3. Fonsecaea monophora黑素对巨噬细胞自噬的影响及机制研究，国家自然科学基金（面上项目），资助金额：60万，2017.01-2020.12；项目批准号：81671992；项目负责人：席丽艳
4. APDT影响着色芽生菌病病原菌毒力及宿主局部免疫的研究，国家自然科学基金（面上项目），资助金额：70万，2014.01-2017.12；项目批准号：81371747；项目负责人：席丽艳
5. 艾滋病、结核等慢性传染病并发侵袭性真菌感染现代早期诊断技术平台的建立——马尔尼菲青霉感染早期诊断技术平台的建立（子项目），国家科技重大专项，资助金额：75.8万，2013.01-2015.12；项目批准号：2013ZX10004612；子项目负责人：席丽艳
6. 脂肪酸代谢途径对马尔尼菲青霉致病性影响的机制研究，国家自然科学基金（面上项目），资助金额：58万，2012.01-2015.12；项目批准号：81171545；项目负责人：席丽艳
7. Hog1-MAPK信号途径在着色霉菌应激反应及致病性中的作用研究，高等学校博士学科点专项科研基金项目，资助金额：6万，2011.01-2013.12；项目批准号：20100171110068；项目负责人：席丽艳
个人成果
近10年第一作者或通讯作者发表的代表性文章
(1) Li M, Huang H, Liu J, Zhang X, Li Q, Li D, Luo M, Wang X, Zeng W, Sun J, Liu H, Xi L. Deletion C-terminal thioesterase abolishes melanin biosynthesis, affects metabolism and reduces the pathogenesis of Fonsecaea monophora. PLoS Negl Trop Dis. 2022 Jun 13;16(6):e0010485.
(2) Liu, H., Sun, J., Li, M., Cai, W., Chen, Y., Liu, Y., Huang, H., Xie, Z., Zeng, W., and Xi, L. Molecular Characteristics of Regional Chromoblastomycosis in Guangdong, China: Epidemiological, Clinical, Antifungal Susceptibility, and Serum Cytokine Profiles of 45 Cases. Frontiers in Cellular and Infection Microbiology 2022. doi: 10.3389/fcimb.2022.810604.
(3) He L, Mei X, Lu S, Ma J, Hu Y, Mo D, Chen X, Fan R, Xi L, Xie T. Talaromyces marneffei infection in non-HIV-infected patients in mainland China. Mycoses. 2021; 64, 1170-1176.
(4) Zhang J*, Zhang Y, Qin J, Lu S, Cai W, Li J, Huang H, Yang S, Xi L. Comparison of a fractional 2940-nm Er:YAG laser and 5% amorolfine lacquer combination therapy versus a 5% amorolfine lacquer monotherapy for the treatment of onychomycosis: a randomized controlled trial. Lasers Med Sci 2020; 36(1):147-152
(5) Hu Y, Lu S, Xi L. Murine Macrophage Requires CD11b to Recognize Talaromyces marneffei. Infect Drug Resist 2020;13:911-920
(6) Feng J, Chen Z, He L, Xiao X, Chen C, Chu J, Mylonakis E, Xi L*: AcuD Gene Knockout Attenuates the Virulence of Talaromyces marneffei in a Zebrafish Model. MYCOBIOLOGY 2019, 47(2):207-216.
(7) Feng J, He L, Xiao X, Chen Z, Chen C, Chu J, Lu S, Li X, Mylonakis E, Xi L*: Methylcitrate cycle gene MCD is essential for the virulence of Talaromyces marneffei. MED MYCOL 2019.
(8) Feng J, Chen C, He L, Xiao X, Chen C, Zhang J, Mylonakis E, Xi L*: Molecular cloning and stable knockout strain construction of the AcuE gene in Talaromyces marneffei. INT J CLIN EXP MED 2019, 12(4):3492-3499.
(9) Liu Y, Huang X, Liu H, Xi L*, Cooper CR*: Increased virulence of albino mutant of Fonsecaea monophora in Galleria mellonella. MED MYCOL 2019, 57(8):1018-1023.
(10) Chen R*, Ji G, Ren H*, Liu Z, Feng S, Zhang T, Xi L*, Li X*: Activation of autophagy and IL-10 production are regulated by Jun N-terminal kinase 1 and 2 and p38 mitogen activated protein kinase signaling pathways during Talaromyces marneffei infection within dendritic cells. Microb Pathog 2019, 139:103891.
(11) He L, Ma J*, Mei X, Lu S, Li X, Xi L*: Successful treatment of chromoblastomycosis of 10-year duration due to Fonsecaea nubica. MYCOSES 2018, 61(4):231-236.
(12) Chen R*, Ji G, Xi L, Zhang T, Zheng D, Li X*, Ren H*: Role of autophagy in regulating the immune response of dendritic cells to Talaromyces marneffei infection. Microb Pathog 2018, 123:120-125.
(13) Fransisca C, He Y, Chen Z, Liu H, Xi L*: Molecular identification of chromoblastomycosis clinical isolates in Guangdong. MED MYCOL 2017, 55(8):851-858.
(14) Yi X, Fransisca C, He Y, Liu Y, Lu S, He L, Xi L*: Photodynamic effects on Fonsecaea monophora conidia and RAW264.7 in vitro. J Photochem Photobiol B 2017, 176:112-117.
(15) He L, Feng J, Lu S, Chen Z, Chen C, He Y, Yi X, Xi L*: Genetic transformation of fungi. INT J DEV BIOL 2017, 61(6-7):375-381.
(16) Zhang J, Lu S, Huang H, Li X, Cai W, Ma J, Xi L*: Combination therapy for onychomycosis using a fractional 2940-nm Er:YAG laser and 5 % amorolfine lacquer. Lasers Med Sci 2016, 31(7):1391-1396.
(17) Liu Y, Huang X, Yi X, He Y, Mylonakis E, Xi L*: Detection of Talaromyces marneffei from Fresh Tissue of an Inhalational Murine Pulmonary Model Using Nested PCR. PLOS ONE 2016, 11(2):e149634.
(18) Lu S, Li X, Calderone R, Zhang J, Ma J, Cai W, Xi L*: Whole blood Nested PCR and Real-time PCR amplification of Talaromyces marneffei specific DNA for diagnosis. MED MYCOL 2016, 54(2):162-168.
(19) Chen R, Ji G, Wang L, Ren H, Xi L*: Activation of ERK1/2 and TNF-alpha production are regulated by calcium/calmodulin signaling pathway during Penicillium marneffei infection within human macrophages. Microb Pathog 2016, 93:95-99.
(20) Lu S, Zhang J, Liang Y, Li X, Cai W, Xi L*: The Efficacy and Prognostic Factors for Long Pulse Neodymium: Yttrium-Aluminum-Garnet Laser Treatment on Onychomycosis: A Pilot Study. ANN DERMATOL 2016, 28(3):406-408.
(21) Ma T, Chen R, Li X, Lu C, Xi L*: The in vitro fungicidal activity of human macrophages against Penicillium marneffei is suppressed by dexamethasone. Microb Pathog 2015, 86:26-31.
(22) Huang X, Li D, Xi L*, Mylonakis E*: Galleria mellonella Larvae as an Infection Model for Penicillium marneffei. MYCOPATHOLOGIA 2015, 180(3-4):159-164.
(23) Chen R, Ji G, Ma T, Huang X, Ren H, Xi L*: Role of intracellular free calcium in killing Penicillium marneffei within human macrophages. Microb Pathog 2015, 83-84:29-34.
(24) Huang X, He G, Lu S, Liang Y, Xi L*: Role of Rhizomys pruinosus as a natural animal host of Penicillium marneffei in Guangdong, China. MICROB BIOTECHNOL 2015, 8(4):659-664.
(25) Hu Y, Huang X, Lu S, Hamblin MR, Mylonakis E, Zhang J, Xi L*: Photodynamic therapy combined with terbinafine against chromoblastomycosis and the effect of PDT on Fonsecaea monophora in vitro. MYCOPATHOLOGIA 2015, 179(1-2):103-109.
(26) Huang X, Li D, Xi L*, Mylonakis E*: Caenorhabditis elegans: a simple nematode infection model for Penicillium marneffei. PLOS ONE 2014, 9(9):e108764.
(27) Chen R, Li X, Lu S, Ma T, Huang X, Mylonakis E, Liang Y, Xi L*: Role of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways in regulating replication of Penicillium marneffei in human macrophages. MICROBES INFECT 2014, 16(5):401-408.
(28) Sun J, Li X, Feng P, Zhang J, Xie Z, Song E*, Xi L*: RNAi-mediated silencing of fungal acuD gene attenuates the virulence of Penicillium marneffei. MED MYCOL 2014, 52(2):167-178.
(29) Lu S, Hu Y, Lu C, Zhang J, Li X, Xi L*: Development of in vitro macrophage system to evaluate phagocytosis and intracellular fate of Penicillium marneffei conidia. MYCOPATHOLOGIA 2013, 176(1-2):11-22.
(30) Lu S, Lu C, Zhang J, Hu Y, Li X, Xi L* Chromoblastomycosis in Mainland China: a systematic review on clinical characteristics. MYCOPATHOLOGIA 2013, 175(5-6):489-495.
(31) Hu Y, Zhang J, Li X, Yang Y, Zhang Y, Ma J, Xi L*: Penicillium marneffei infection: an emerging disease in mainland China. MYCOPATHOLOGIA 2013, 175(1-2):57-67.
(32) Sun J, Najafzadeh MJ, Gerrits VDEA, Vicente VA, Feng P, Xi L*, De Hoog GS*: Molecular characterization of pathogenic members of the genus Fonsecaea using multilocus analysis. PLOS ONE 2012, 7(8):e41512.
(33) Yang Y, Hu Y, Zhang J, Li X, Lu C, Liang Y, Xi L*: A refractory case of chromoblastomycosis due to Fonsecaea monophora with improvement by photodynamic therapy. MED MYCOL 2012, 50(6):649-653.
(34) Xie Z, Feng P, Zhang J, Li X, Sun J, Lu C, Huang H, Xi L*: Molecular cloning, characterization and differential expression of Cdc42 in Fonsecaea monophora. MOL BIOL REP 2012, 39(2):839-844.
(35) Lu S, Xi L, Qin W, Luo Y, Lu C, Li X*: Cutaneous protothecosis: two new cases in China and literature review. INT J DERMATOL 2012, 51(3):328-331.
2. 专病慢病管理信息系统. 计算机软件著作权. 2020（2021SR0794740）. 第一申请人
其他科技成就
1. 2014年华夏医疗保健国际交流促进科技奖三等奖，获奖题目“马尔尼菲青霉毒力因子相关研究”。
2. 主编《常见真菌感染性疾病直接镜检图谱》2020年广东科技出版社出版的图书